Decreased plasma agmatine levels in autistic subjects

被引：0
作者：
Erman Esnafoglu
İlhan İrende
机构：
[1] Ordu University,Department of Child and Adolescent Psychiatry, Faculty of Medicine, Research and Training Hospital
[2] Ordu University Central Research Laboratory,Department of Chemistry, Faculty of Science and Art
[3] Ordu University,undefined
来源：
Journal of Neural Transmission | 2018年 / 125卷
关键词：
Autism spectrum disorder; Autism; Agmatine; Polyamines; Pathogenesis; NMDA receptors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Agmatine is a polyamine endogenously synthesized from arginine and is considered to be a new neurotransmitter. Agmatine has been implicated in the pathophysiology of several diseases such as anxiety disorder, depression, and schizophrenia. Agmatine also possesses anticonvulsant, neuroprotective, antiapoptotic, antioxidant, anxiolytic, and antidepressant effects. Furthermore, agmatine inhibits the nitric oxide synthase enzyme and exerts antagonist effects on NMDA, alpha-2, and imidazoline receptors. Considering these characteristics, the present study investigated whether agmatine plays a role in the pathogenesis of autistic spectrum disorders (ASDs). Therefore, plasma agmatine levels were evaluated in 34 patients with ASD and 28 non-ASD controls. Plasma agmatine levels were measured using the HPLC method. The study found remarkably lower agmatine levels in patients with ASD compared with the non-ASD control group (p < 0.001). These findings support the notion that agmatine might contribute to the pathogenesis of ASD and may serve as a new target for treatment.
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页码：735 / 740
页数：5
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