LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses

被引:0
作者
Shao-hua Wang
Yan Huang
Yang Yuan
Wen-qing Xia
Pin Wang
Rong Huang
机构
[1] ZhongDa Hospital of Southeast University,Department of Endocrinology
[2] YanCheng First People’s Hospital,Department of Endocrinology
来源
Lipids in Health and Disease | / 13卷
关键词
LDL receptor knock-out; Cognition; Synapse; Apoptosis;
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[1]  
Puglielli L(2003)Alzheimer’s disease: the cholesterol connection Nat Neurosci 6 345-351
[2]  
Tanzi RE(2010)Cholesterol-related genes in Alzheimer’s disease Biochim Biophys Acta 1801 762-773
[3]  
Kovacs DM(1995)Correlation of severity and outcome with plasma sterol levels in variants of the Smith-Lemli-Opitz syndrome J Pediatr 127 82-87
[4]  
Wollmer MA(2005)Niemann-Pick type C disease and intracellular cholesterol trafficking J Biol Chem 280 20917-20920
[5]  
Tint G(2000)Statins and the risk of dementia Lancet 356 1627-1631
[6]  
Salen G(1995)Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer’s disease a case‒control study Neurology 45 1092-1096
[7]  
Batta AK(2002)Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease Ann Intern Med 137 149-1297
[8]  
Shefer S(2001)Cholesterol–making or breaking the synapse Science 294 1296-43242
[9]  
Irons M(2005)Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease J Biol Chem 280 43236-101
[10]  
Elias ER(2003)Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer’s disease Trends Mol Med 9 94-12