Role of cardiac resynchronization therapy in asymptomatic and mildly symptomatic heart failure

被引：0

作者：

Forcina M.S. ^{[1
]}

Gold M.R. ^{[1
]}

机构：

[1] Medical University of South Carolina, Charleston, SC 29425

来源：

Current Heart Failure Reports | 2009年 / 6卷 / 1期

关键词：

Cardiac Resynchronization Therapy; Ventricular Assist Device; Reverse Remodel; Heart Failure Hospitalization; Biventricular Pace;

D O I：

10.1007/s11897-009-0008-6

中图分类号：

学科分类号：

摘要：

Cardiac resynchronization therapy (CRT) improves quality of life, left ventricular (LV) size and function, and mortality among moderate to severe symptomatic congestive heart failure (CHF) patients with decreased LV ejection fraction and QRS prolongation. Whether these benefits extend to similar groups with minimal or mild CHF is an area of ongoing investigation. Two small studies with limited follow-up demonstrated reverse remodeling but no symptomatic improvement. A recent, larger study in a population of asymptomatic or mildly symptomatic CHF patients with longer follow- up confirmed the beneficial effect of CRT on LV size and function; furthermore, it was the first study to show that CRT improves clinical outcome with delayed time to heart failure hospitalization. Ongoing trials of CRT in such patients will soon provide further data on morbidity and mortality. © Current Medicine Group, LLC 2009.

引用

页码：44 / 48

页数：4

共 19 条

[1]

Cazeau S., Leclercq C., Lavergne T., Et al., Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay, N Engl J Med, 344, pp. 873-880, (2001)

[2]

Abraham W.T., Fisher W.G., Smith A.L., Et al., Cardiac resynchronization in chronic heart failure, N Engl J Med, 346, pp. 1845-1853, (2002)

[3]

Young J.B., Abraham W.T., Smith A.L., Et al., Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: The MIRACLE ICD Trial, JAMA, 289, pp. 2685-2694, (2003)

[4]

Bristow M.R., Saxon L.A., Boehmer J., Et al., Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure, N Engl J Med, 350, pp. 2140-2150, (2004)

[5]

Cleland J.G., Daubert J.C., Erdmann E., Et al., The effect of cardiac resynchronization on morbidity and mortality in heart failure, N Engl J Med, 352, pp. 1539-1549, (2005)

[6]

St John Sutton M.G., Plappert T., Abraham W.T., Et al., Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure, Circulation, 107, pp. 1985-1990, (2003)

[7]

Diaz-Infante E., Mont L., Leal J., Et al., Predictors of lack of response to resynchronization therapy, Am J Cardiol, 95, pp. 1436-1440, (2005)

[8]

Yu C.M., Bleeker G.B., Fung J.W., Et al., Left ventricular reverse remodelling but not clinical improvement predicts long term survival after cardiac resynchronization therapy, Circulation, 112, pp. 1580-1586, (2005)

[9]

Hunt S.A., Abraham W.T., Chin M.H., Et al., ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure), Circulation, 112, (2005)

[10]

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S) [no authors listed], Lancet, 344, pp. 1383-1389, (1994)

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