Effect of Gender and Age on the Pharmacokinetics of Repinotan

被引：0
|
作者：
Roland Heinig
Pavur Sundaresan
Anita Shah
Michael Boettcher
机构：
[1] Bayer HealthCare AG,Institute of Clinical Pharmacology
[2] Bayer Pharmaceuticals Corporation,Department of Clinical Pharmacology
[3] Bayer Pharmaceuticals Corporation,Preclinical Drug Development
来源：
Clinical Drug Investigation | 2005年 / 25卷
关键词：
Dextromethorphan; Extensive Metaboliser; Debrisoquine; Metabolic Ratio; Sparteine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: Repinotan hydrochloride (repinotan) is a selective, high-affinity, full serotonin receptor agonist at the 5-HT1a subtype that is undergoing clinical development in acute stroke. To investigate whether gender is an important covariable for repinotan pharmacokinetics, two studies were performed in subjects of different age and gender who had been phenotyped as extensive metabolisers for cytochrome P450 (CYP)2D6 using dextromethorphan as model substrate.
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页码：125 / 134
页数：9
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