Plasmablastic lymphoma in the ano-rectal junction presenting in an immunocompetent man: A case report

被引：20

作者：

Brahmania M. ^{[1
]}

Sylwesterowic T. ^{[1
]}

Leitch H. ^{[1
]}

机构：

[1] Department of Medicine, Division of Gastroenterology and Hematology, St Paul's Hospital, Vancouver

来源：

Journal of Medical Case Reports | / 5卷 / 1期

关键词：

Human Immunodeficiency Virus; Serum Protein Electrophoresis; Immunoglobulin Light Chain; Plasmablastic Lymphoma; Atypical Lymphoid Cell;

D O I：

10.1186/1752-1947-5-168

中图分类号：

学科分类号：

摘要：

Introduction. Plasmablastic lymphoma is an aggressive non-Hodgkin lymphoma classically occurring in individuals infected with HIV. Plasmablastic lymphoma has a predilection for the oral cavity and jaw. However, recent case reports have shown lymphoma in the stomach, lung, nasal cavity, cervical lymph nodes and jejunum in HIV-negative individuals. We report what is, to the best of our knowledge, the first case of plasmablastic lymphoma occurring in the ano-rectal junction of an HIV-negative man. Case Presentation. A previously healthy 59-year-old Caucasian man presented with painless rectal bleeding. Colonoscopy revealed a lesion in the ano-rectal junction, with pathological examination demonstrating atypical lymphoid cells consisting primarily of plasmablasts with rounded nuclei, coarse chromatin, small nucleoli and multiple mitotic figures. Immunohistochemical analysis showed the atypical cells were negative for CD45, CD20, CD79a and immunoglobulin light chains, but were strongly positive for CD138 and EBV-encoded RNA. The results were consistent with a diagnosis of plasmablastic lymphoma. Aggressive systemic chemotherapy and involved field radiation therapy resulted in complete clinical and pathological remission. Conclusion: Increasing awareness of plasmablastic lymphoma in HIV-negative individuals and in this location is warranted. © 2011 Brahmania et al; licensee BioMed Central Ltd.

引用

共 30 条

[1]

Delecluse H.J., Anagnostopoulos I., Dallenbach F., Hummel M., Marafioti T., Schneider U., Huhn D., Schmidt-Westhausen A., Reichart P.A., Gross U., Stein H., Plasmablastic lymphomas of the oral cavity: A new entity associated with the human immunodeficiency virus infection, Blood, 89, 4, pp. 1413-1420, (1997)

[2]

Flaitz C.M., Nichols C.M., Walling D.M., Hicks M.J., Plasmablastic lymphoma: An HIV-associated entity with primary oral manifestations, Oral Oncology, 38, 1, pp. 96-102, (2002)

[3]

Carbone A., Ferlito A., Gaidano G., Rinaldo A., Gloghini A., Stein H., Aids-related plasmablastic lymphomas of the oral cavity and jaws: A diagnostic dilemma, Annals of Otology, Rhinology and Laryngology, 108, 1, pp. 95-99, (1999)

[4]

Jambusaria A., Shafer D., Wu H., Al-Saleem T., Perlis C., Cutaneous plasmablastic lymphoma, Journal of the American Academy of Dermatology, 58, 4, pp. 676-678, (2008)

[5]

Lim J.H., Lee M.H., Lee M.J., Kim C.S., Lee J.S., Choi S.J., Yi H.G., Plasmablastic lymphoma in the anal canal, Cancer Res Treat, 41, 3, pp. 182-185, (2009)

[6]

Valenzuela A.A., Walker N.J., Sullivan T.J., Plasmablastic lymphoma in the orbit: Case report, Orbit, 27, 3, pp. 227-229, (2008)

[7]

Nasta S.D., Carrum G.M., Shahab I., Hanania N.A., Udden M.M., Regression of a plasmablastic lymphoma in a patient with HIV on highly active antiretroviral therapy, Leukemia and Lymphoma, 43, 2, pp. 423-426, (2002)

[8]

Nguyen D.D., Loo Jr. B.W., Tillman G., Natkunam Y., Cao T.M., Vaughan W., Dorfman R.F., Goffinet D.R., Jacobs C.D., Advani R.H., Plasmablastic lymphoma presenting in a human immunodeficiency virus-negative patient: A case report, Annals of Hematology, 82, 8, pp. 521-525, (2003)

[9]

Lin Y., Rodrigues G.D., Turner J.F., Vasef M.A., Plasmablastic lymphoma of the lung: Report of a unique case and review of the literature, Archives of Pathology and Laboratory Medicine, 125, 2, pp. 282-285, (2001)

[10]

Pruneri G., Graziadei G., Ermellino L., Baldini L., Neri A., Buffa R., Plasmablastic lymphoma of the stomach. A case report, Haematologica, 83, 1, pp. 87-89, (1998)

← 1 2 3 →