Clinical Pharmacology and Therapeutic Potential of Monoclonal Antibody Treatment in Rheumatoid Arthritis

被引：0
|
作者：
Ernest H. S. Choy
机构：
[1] Guy’s and King’s College Hospitals,Rheumatology Unit
[2] Guy’s Hospital,Rheumatology Unit, 5th Floor, Thomas Guy House
来源：
Drugs & Aging | 1998年 / 12卷
关键词：
Rheumatoid Arthritis; Adis International Limited; Synovial Fluid; Rheumatol; Synovial Joint;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Many monoclonal antibodies (mAb) have been tested in rheumatoid arthritis (RA). Murine antibodies were antigenic and caused human antimouse responses in the recipients. As a result, re-treatments were less effective and were associated with an increased risk of anaphylaxis. Advances in biotechnology have allowed us to develop chimaeric and humanised mAb that are less antigenic than their murine equivalents.
引用
收藏
页码：139 / 148
页数：9
相关论文
共 50 条
  • [21] Therapeutic Potential of Nanocarriers in the Management of Rheumatoid Arthritis
    Mittal, Vishnu
    Sharma, Anjali
    Sharma, Devkant
    CURRENT RHEUMATOLOGY REVIEWS, 2024,
  • [22] Visfatin: a Potential Therapeutic Target for Rheumatoid Arthritis
    Bao, J. P.
    Chen, W. P.
    Wu, L. D.
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2009, 37 (06) : 1655 - 1661
  • [23] Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy
    Zhao, Ting
    Yang, Qi
    Xi, Yujiang
    Xie, Zhaohu
    Shen, Jiayan
    Li, Zhenmin
    Li, Zhaofu
    Qin, Dongdong
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [24] TREATMENT OF SEVERE RHEUMATOID-ARTHRITIS BY ANTI-INTERLEUKIN-6 MONOCLONAL-ANTIBODY
    WENDLING, D
    RACADOT, E
    WIJDENES, J
    JOURNAL OF RHEUMATOLOGY, 1993, 20 (02) : 259 - 262
  • [25] MAVRILIMUMAB Human monoclonal GM-CSF-R-α antibody Treatment of rheumatoid arthritis MONOGRAPH
    Karumanchery, R.
    Nair, J. R.
    Moots, R. J.
    DRUGS OF THE FUTURE, 2016, 41 (04) : 221 - 228
  • [26] Efficacy of berberine in treatment of rheumatoid arthritis: From multiple targets to therapeutic potential
    Huang, Dan-na
    Wu, Fang-fang
    Zhang, Ai-hua
    Sun, Hui
    Wang, Xi-jun
    PHARMACOLOGICAL RESEARCH, 2021, 169
  • [27] Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation
    Aihaiti, Yirixiati
    Song Cai, Yong
    Tuerhong, Xiadiye
    Ni Yang, Yan
    Ma, Yao
    Shi Zheng, Hai
    Xu, Ke
    Xu, Peng
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [28] Liver X receptors conserve the therapeutic target potential for the treatment of rheumatoid arthritis
    Mai, Chu-Tian
    Zheng, De-Chong
    Li, Xin-Zhi
    Zhou, Hua
    Xie, Ying
    PHARMACOLOGICAL RESEARCH, 2021, 170
  • [29] The treatment of rheumatoid arthritis using Chinese medicinal plants: From pharmacology to potential molecular mechanisms
    Lu, Shaowa
    Wang, Qiushi
    Li, Guoyu
    Sun, Shuang
    Guo, Yuyan
    Kuang, Haixue
    JOURNAL OF ETHNOPHARMACOLOGY, 2015, 176 : 177 - 206
  • [30] Exploring Potential Bioactive Components of Persea americana for the Treatment of Rheumatoid Arthritis through Network Pharmacology
    Swaroop, Akey Krishna
    Esakkimuthukumar, M.
    Saranya, R.
    Chandru, M.
    Sowbarnika, S.
    Sudharsan, J.
    Dhanush, V
    Prabha, Thangavelu
    Jubie, S.
    CURRENT RHEUMATOLOGY REVIEWS, 2024,
12345