Non-steroidal anti-inflammatory drugs (NSAIDs) and gastro-intestinal toxicity: Current issues

被引：0
作者：
A. A. Shah
D. J. Fitzgerald
F. E. Murray
机构：
[1] Royal College of Surgeons in Ireland,Department of Medicine/Gastroenterology
[2] Royal College of Surgeons in Ireland,Clinical Pharmacology
[3] Beaumont Hospital,Department of Gastroenterology
[4] Beaumont Hospital,undefined
[5] Beaumont,undefined
来源：
Irish Journal of Medical Science | 1999年 / 168卷
关键词：
Naproxen; Nimesulide; Etodolac; Faecal Calprotectin; Tiaprofenic Acid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs and their widespread use is associated with increased gastro-intestinal toxic effects such as ulceration, haemorrhage, perforation and death. They result in these complications mainly by reducing cytoprotective prostaglandins (PGE2 and PGI2) in the stomach, through the inhibition of cyclo-oxygenase (COX) enzyme. The increased morbidity and mortality, in addition to enormous cost, associated with NSAID-associated side effects, necessitates a need for safer GI-friendly NSAID.
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页码：242 / 245
页数：3
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