The adaptive effects of hypoxic preconditioning of brain neurons

被引：45
作者：
M. O. Samoilov
E. V. Lazarevich
D. G. Semenov
A. A. Mokrushin
E. I. Tyul'kova
D. Yu. Romanovskii
E. A. Milyakova
K. N. Dudkin
机构：
[1] I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 199034 St. Petersburg
[2] Medical Research Center, Polish Academy of Sciences, Warsaw
来源：
Neuroscience and Behavioral Physiology | 2003年 / 33卷 / 1期
基金：
俄罗斯基础研究基金会;
关键词：
Hypoxia; Olfactory slices; Preconditioning;
D O I：
10.1023/A:1021119112927
中图分类号：
学科分类号：
摘要：
Prophylactic transient hypoxia (preconditioning) increased neuron resistance to subsequent induction of severe hypoxia. Published data and results obtained by the authors on the molecular-cellular mechanisms of hypoxic preconditioning are presented. The roles of intracellular signal transduction, genome function, stress proteins, and neuromodulatory peptides in this process are discussed. The roles of glutamatergic as well as calcium and phosphoinositide regulatory systems and neuromodulatory factors as components of volume" signal transmission are analyzed in hypoxic preconditioning-associated induction of functional tolerance mechanisms against the acute harmful effects of hypoxia on neurons in olfactory slices."
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页码：1 / 11
页数：10
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