The Adaptive Effects of Hypoxic Preconditioning of Brain Neurons

被引：45
|
作者：
M. O. Samoilov
E. V. Lazarevich
D. G. Semenov
A. A. Mokrushin
E. I. Tyul'kova
D. Yu. Romanovskii
E. A. Milyakova
K. N. Dudkin
机构：
[1] I. P. Pavlov Institute of Physiology,
[2] Russian Academy of Sciences,undefined
[3] Medical Research Center,undefined
[4] Polish Academy of Sciences,undefined
来源：
Neuroscience and Behavioral Physiology | 2003年 / 33卷 / 1期
关键词：
preconditioning; hypoxia; olfactory slices;
D O I：
10.1023/A:1021119112927
中图分类号：
学科分类号：
摘要：
A preventive short-term hypoxia (preconditioning) increases neuronal resistance against subsequent strong hypoxic effects. Literature review and authors' own data on molecular-cellular mechanisms of the hypoxic preconditioning, are presented. Participation of intracellular signal transduction, genome, stress-proteins, and neuromodulating peptides in this process, is discussed. The role of glutamatergic as well as calcium and phosphoinositide regulatory systems and neuromodulating factors as the components of a “volume” signal transmission are analyzed in hypoxic precondition-associated induction of functional tolerance mechanisms against acute harmful effects in neurones of olfactory slices.
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页码：1 / 11
页数：10
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