Quantum Chemical Studies on Structure Activity Relationship of Natural Product Polyacetylenes

被引：0
作者：
Mire Zloh
Franz Bucar
Simon Gibbons
机构：
[1] University of London,Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy
[2] University of Graz,Department of Pharmacognosy, Institute of Pharmaceutical Sciences
[3] University of London,Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy
来源：
Theoretical Chemistry Accounts | 2007年 / 117卷
关键词：
Antimycobacterial activity; Polyacetylenes; Falcarindiol; log ;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An extract of the roots of Levisticum officinale L. (Apiaceae) exhibited significant antimycobacterial activity against Mycobacterium fortuitum, where diacetylene compounds were identified as the active components in this extract. In contrast, polyacetylenes isolated from different sources surprisingly exhibited no anti-mycobacterial activity. Additionally, a whole series of furanocoumarin ethers of the polyacetylene falcarindiol exhibited anti-proliferative properties. We have studied the relationship between the electronic properties and biological activity of these structurally related compounds and a good qualitative correlation between predicted lipophilic parameters and activity has been established.
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页码：247 / 252
页数：5
相关论文
共 95 条
  • [1] Uwai K(2000)undefined J Med Chem 43 4508-4515
  • [2] Ohashi K(1997)undefined J Nat Prod 60 1210-undefined
  • [3] Takaya Y(2004)undefined Phytochemistry 64 331-undefined
  • [4] Ohta T(1996)undefined J Nat Prod 59 748-undefined
  • [5] Tadano T(1989)undefined Physiol Mol Plant P 34 545-undefined
  • [6] Kisara K(2004)undefined J Nat Prod 67 892-undefined
  • [7] Shibusawa K(1998)undefined Bioorg Med Chem Lett 8 93-undefined
  • [8] Sakakibara R(1990)undefined J Comput Chem 11 440-undefined
  • [9] Oshima Y(1990)undefined J Am Chem Soc 112 6127-undefined
  • [10] Kobaisy M(1993)undefined J Comput Chem 14 1347-undefined
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