ALASKA: A Mathematica package for two-state kinetic analysis of protein folding reactions

被引：0
|
作者：
Rendall E. Burton
Richard S. Busby
Terrence G. Oas
机构：
[1] Duke University Medical Center,Department of Biochemistry
来源：
Journal of Biomolecular NMR | 1998年 / 11卷
关键词：
dynamic NMR; kinetics; line shape simulation; protein folding;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A Mathematica package (ALASKA) has been developed to simplify the measurement of protein folding kinetics by analysis of 1H NMR lineshape analysis. This package reads NMR data in ASCII format and can simulate an aromatic 1 NMR spectrum with or without lineshape broadening from chemical exchange. We describe the analysis of a urea denaturation series of a fast-folding protein, the G46A/G48A variant of monomeric λ repressor.
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页码：355 / 360
页数：5
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