The use of novel selectivity metrics in kinase research

[1] Kola I(2004)Opinion: Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3 711-716

[2] Landis J(2002)The protein kinase complement of the human genome Science 298 1912-1934

[3] Manning G(2009)Selectivity and therapeutic inhibition of kinases: to be or not to be? Nat Immunol 10 356-360

[4] Whyte DB(2012)Cyclin-dependent kinase inhibitors move into Phase III Nat Rev Drug Discov 11 892-894

[5] Martinez R(2006)Can we rationally design promiscuous drugs? Curr Opin Struct Biol 16 127-136

[6] Hunter T(2014)Polypharmacology: Challenges and Opportunities in Drug Discovery: Miniperspective J Med Chem 57 7874-7887

[7] Sudarsanam S(2008)From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage Curr Med Chem 15 422-432

[8] Ghoreschi K(2010)Targeting the cancer kinome through polypharmacology Nat Rev Cancer 10 130-137

[9] Laurence A(2008)Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery J Med Chem 51 7898-7914

[10] O’Shea JJ(2005)Cellular targets of gefitinib Cancer Res 65 379-382

[1] Kola I(2004)Opinion: Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3 711-716

[2] Landis J(2002)The protein kinase complement of the human genome Science 298 1912-1934

[3] Manning G(2009)Selectivity and therapeutic inhibition of kinases: to be or not to be? Nat Immunol 10 356-360

[4] Whyte DB(2012)Cyclin-dependent kinase inhibitors move into Phase III Nat Rev Drug Discov 11 892-894

[5] Martinez R(2006)Can we rationally design promiscuous drugs? Curr Opin Struct Biol 16 127-136

[6] Hunter T(2014)Polypharmacology: Challenges and Opportunities in Drug Discovery: Miniperspective J Med Chem 57 7874-7887

[7] Sudarsanam S(2008)From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage Curr Med Chem 15 422-432

[8] Ghoreschi K(2010)Targeting the cancer kinome through polypharmacology Nat Rev Cancer 10 130-137

[9] Laurence A(2008)Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery J Med Chem 51 7898-7914

[10] O’Shea JJ(2005)Cellular targets of gefitinib Cancer Res 65 379-382