Cadmium Toxicity in Spermatogenesis and Protective Effects of l-Carnitine in Adult Male Rats

被引：0
作者：
Abazar Yari
Mohammad Hossein Asadi
Hossein Bahadoran
Hossein Dashtnavard
Hossein Imani
Mohammad Reza Naghii
机构：
[1] University of Medical Sciences,Department of Anatomy, Faculty of Medicine, Baqiyatallah
[2] University of Medical Sciences,Department of Nutrition, Faculty of Health, Baqiyatallah
来源：
Biological Trace Element Research | 2010年 / 137卷
关键词：
-Carnitine; Cadmium toxicity; Spermatogenesis; Mature male rat;
D O I：
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学科分类号：
摘要：
In this study, the effects of cadmium toxicity and the protective effects of l-carnitine on spermatogenesis in Sprague–Dawley rat were evaluated. Animals were subdivided into five groups. Cadmium chloride (1-mg/kg body weight) was injected intraperitoneally during 16 days at intervals of 48 h between subsequent treatments. l-Carnitine (500 mg/kg b.w., IP) was pretreated in both of control and cadmium-injected rats. Animals were killed on day 17 after the first treatment. The left cauda epididymis was removed and immediately immersed into Hank’s balanced salt solution for evaluation of sperm count and viability. Following contamination with cadmium, a decrease in the number and viability of cauda epididymis sperm, the number of cell proliferation, and Johnsen Scores in the seminiferous tubules was observed. Consequently, l-carnitine treatment caused an increase in the number and viability of cauda epididymis sperm, the number of cell proliferation, and Johnsen Scores in the cadmium-induced group.
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页码：216 / 225
页数：9
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