Pulse corticosteroid therapy with methylprednisolone or dexamethasone

被引：26

作者：

Hari P. ^{[1
]}

Srivastava R.N. ^{[1
,2
]}

机构：

[1] Department of Pediatrics, All India Inst. of Medical Sciences, New Delhi

[2] New Delhi 110 019

来源：

The Indian Journal of Pediatrics | 1998年 / 65卷 / 4期

关键词：

Adverse reactions; Dexamethasone; Methylprednisolone; Pulse therapy;

D O I：

10.1007/BF02730894

中图分类号：

学科分类号：

摘要：

Intravenous pulse steroid therapy consists of administration of supraphysiological doses of glucocorticoids. It is useful in conditions where rapid immunosuppression and anti-inflammatory effect is desired, as in systemic lupus erythematosus, pemphigus, renal transplantation, steroid resistant nephrotic syndrome and crescentic glomerulonephritis. This therapy may be associated with significant adverse reactions including hypertension, arrhythmias, hypokalemia, psychosis and infections. High dose steroid therapy should therefore be used in selected cases and under careful supervision. The drug most widely used for this treatment is methylprednisolone. However, in view of its easy availability and cost, dexamethasone has been often used in India for the above conditions. While there are no controlled studies comparing the two drugs, it appears that the two drugs may be similar in efficacy. Patients requiring high dose intravenous steroid therapy may be treated effectively with either methylprednisolone or dexamethasone.

引用

页码：557 / 560

页数：3

共 7 条

[1]

Ontjes D.A., Adrenal corticosteroids, Principles of Pharmacology : Basic Concepts and Clinical Application, pp. 749-787, (1995)

[2]

Wilson J.W., Cellular localisation of 3H-labelled corticosteroids by electron microscopic autoradiography after hemorrhagic shock, Steroids and Shock, pp. 275-299, (1974)

[3]

Quandt C.M., Reyes R.A., Pharmacologic management of acute intracranial hypertension, Drug Intell & Clin Pharma, 18, (1984)

[4]

Pasricha J.A., Khaitan B.K., Shantha Raman R., Chandra M., Dexamethasone cyclophosphamide pulse therapy for pemphigus, Int J Dermatol, 34, pp. 875-882, (1995)

[5]

Anderson J.C., Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy, N Engl J Med, 330, pp. 1560-1564, (1994)

[6]

Sprung C.L., Panagiota V., Caralis M.D., Et al., The effects of high dose corticosteroids in patients with septic shock, N Engl J Med, 311, (1984)

[7]

Schummer J.C., Steroids in treatment of clinical septic shock, Ann Surg, 184, pp. 333-341, (1976)

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