Small Cell Neuroendocrine Carcinoma of the Oropharynx Harbouring Oncogenic HPV-Infection

被引：23

作者：

Bates T. ^{[1
,2
]}

McQueen A. ^{[2
]}

Iqbal M.S. ^{[2
]}

Kelly C. ^{[2
]}

Robinson M. ^{[2
]}

机构：

[1] Department of Cellular Pathology, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne

[2] Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne

来源：

Head and Neck Pathology | 2014年 / 8卷 / 1期

关键词：

Human papillomavirus (HPV); Neuroendocrine carcinoma; Oropharynx; Small cell carcinoma;

D O I：

10.1007/s12105-013-0471-y

中图分类号：

学科分类号：

摘要：

Small cell carcinoma/neuroendocrine carcinoma (SCNEC) of the oropharynx is uncommon. Recently, an association has been reported between oropharyngeal SCNEC and high-risk human papillomavirus (HPV) infection. While HPV infection confers a better prognosis for oropharyngeal squamous cell carcinoma, HPV infection does not appear to influence the biological behaviour of SCNECs, which are generally associated with poor clinical outcomes. We document two cases of SCNEC arising in the oropharynx with evidence of high-risk HPV infection. The cases highlight the expanding range of malignant oropharyngeal neoplasms that harbour oncogenic HPV infection and support the concept that, irrespective of HPV infection, neuroendocrine differentiation portends a poor prognosis. © 2013 Springer Science+Business Media New York.

引用

页码：127 / 131

页数：4

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