Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

被引：0
作者：
Xi Chen
Chengsong Xie
Wotu Tian
Lixin Sun
Wang Zheng
Sarah Hawes
Lisa Chang
Justin Kung
Jinhui Ding
Shengdi Chen
Weidong Le
Huaibin Cai
机构：
[1] National Institutes of Health,Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging
[2] Dalian Medical University,Clinical Research Center on Neurological Diseases, the First Affiliated Hospital
[3] Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Department of Neurology
[4] National Institute on Aging,Computational Biology Group, Laboratory of Neurogenetics
[5] National Institutes of Health,undefined
来源：
Molecular Neurodegeneration | / 15卷
关键词：
Parkinson’s disease; LRRK2; Striatal spiny projection neuron; Nuclear hypertrophy; Nuclear invagination; Nuclear DNA damage; Dendritic hypotrophy; G2019S; R1441C; GABAA; Excitability; And aging;
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