Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

被引:0
作者
Xi Chen
Chengsong Xie
Wotu Tian
Lixin Sun
Wang Zheng
Sarah Hawes
Lisa Chang
Justin Kung
Jinhui Ding
Shengdi Chen
Weidong Le
Huaibin Cai
机构
[1] National Institutes of Health,Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging
[2] Dalian Medical University,Clinical Research Center on Neurological Diseases, the First Affiliated Hospital
[3] Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Department of Neurology
[4] National Institute on Aging,Computational Biology Group, Laboratory of Neurogenetics
[5] National Institutes of Health,undefined
来源
Molecular Neurodegeneration | / 15卷
关键词
Parkinson’s disease; LRRK2; Striatal spiny projection neuron; Nuclear hypertrophy; Nuclear invagination; Nuclear DNA damage; Dendritic hypotrophy; G2019S; R1441C; GABAA; Excitability; And aging;
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