Generation of Urine-Derived Induced Pluripotent Stem Cells and Cerebral Organoids for Modeling Down Syndrome

[1] de Graaf G(2015)Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States American Journal of Medical Genetics. Part A 167A 756-767

[2] Buckley F(2020)Estimation of the number of people with Down syndrome in Europe European Journal of Human Genetics 29 402-410

[3] Skotko BG(2022)Association of Alzheimer disease with life expectancy in people with Down syndrome JAMA Network Open 5 e2212910-379

[4] de Graaf G(2013)Cerebral organoids model human brain development and microcephaly Nature 501 373-15677

[5] Buckley F(2019)Complex oscillatory waves emerging from cortical organoids model early human brain network development Cell Stem Cell 558–569 e7-527

[6] Skotko BG(2015)Human cerebral organoids recapitulate gene expression programs of fetal neocortex development Proceedings of the National Academy of Sciences of the United States of America 112 15672-422

[7] Iulita MF(2019)Individual brain organoids reproducibly form cell diversity of the human cerebral cortex Nature 570 523-756.e17

[8] Garzón Chavez D(2019)Organoid single-cell genomic atlas uncovers human-specific features of brain development Nature 574 418-926.e8

[9] Klitgaard Christensen M(2019)Establishing cerebral organoids as models of human-specific brain evolution Cell 176 743-2374

[10] Lancaster MA(2019)OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-Based organoid and chimeric mouse models of Down syndrome Cell Stem Cell 24 908-5788

[1] de Graaf G(2015)Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States American Journal of Medical Genetics. Part A 167A 756-767

[2] Buckley F(2020)Estimation of the number of people with Down syndrome in Europe European Journal of Human Genetics 29 402-410

[3] Skotko BG(2022)Association of Alzheimer disease with life expectancy in people with Down syndrome JAMA Network Open 5 e2212910-379

[4] de Graaf G(2013)Cerebral organoids model human brain development and microcephaly Nature 501 373-15677

[5] Buckley F(2019)Complex oscillatory waves emerging from cortical organoids model early human brain network development Cell Stem Cell 558–569 e7-527

[6] Skotko BG(2015)Human cerebral organoids recapitulate gene expression programs of fetal neocortex development Proceedings of the National Academy of Sciences of the United States of America 112 15672-422

[7] Iulita MF(2019)Individual brain organoids reproducibly form cell diversity of the human cerebral cortex Nature 570 523-756.e17

[8] Garzón Chavez D(2019)Organoid single-cell genomic atlas uncovers human-specific features of brain development Nature 574 418-926.e8

[9] Klitgaard Christensen M(2019)Establishing cerebral organoids as models of human-specific brain evolution Cell 176 743-2374

[10] Lancaster MA(2019)OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-Based organoid and chimeric mouse models of Down syndrome Cell Stem Cell 24 908-5788