High molecular weight poly(l-lactic acid)s by polyesterification using diisopropylcarbodiimide (DIPC) and 4-(dimethylamino) pyridinium-p-toluene sulfonate (DPTS)

High molecular weight poly(l-lactic acid) has been prepared from the corresponding functionally terminated oligomers employing a polyesterification method at room temperature using diisopropylcarbodiimide and 4-(dimethylamino) pyridinium-p-toluene sulfonate. Self-condensation of hydroxyl and carboxylic acid-terminated poly(l-lactic acid) oligomers (Mn: ~1,000) resulted in polymers with high molecular weights (Mn > 45,000) under mild conditions. End-group analysis by MALDI-TOF provided evidence for N-acylurea formation in the product under the reaction conditions employed.