Linkage of schizophrenia with chromosome 1q loci in Taiwanese families

被引:0
作者
H-G Hwu
C-M Liu
C S-J Fann
W-C Ou-Yang
S F-C Lee
机构
[1] National Taiwan University Hospital and National Taiwan University College of Medicine,Department of Psychiatry
[2] National Taiwan University,undefined
[3] Institute of Biomedical Science,undefined
[4] Academia Sinica,undefined
[5] Chianan Psychiatric Center,undefined
[6] Taoyuan Psychiatric Center,undefined
来源
Molecular Psychiatry | 2003年 / 8卷
关键词
schizophrenia; genetic marker; chromosome 1q; linkage; DISC1 gene;
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学科分类号
摘要
A positive linkage of schizophrenia with chromosome 1q loci has been reported in Caucasian patients. This study was designed to evaluate the linkage of schizophrenia with markers of the 1q22–44 region in 52 Taiwanese families with at least two affected siblings. In the region 1q22–31 (17.8 cM), marker D1S1679 had a maximal proportion (0.57, P=0.03) of shared identity by descent (IBD) under a narrow phenotype (DSM-IV schizophrenia only). In the region 1q42–44 (26.8 cM), the marker D1S251, located near the breakpoint of a balanced translocation t (1;11) (q42.1;q14.3) segregated with schizophrenia, and also near the neurodevelopment-related ‘Disrupted in Schizophrenia 1’ gene, had a maximum NPL score of 1.73 (P=0.03) under the narrow phenotype model and 2.18 (P=0.01) under the broad phenotype model comprised of schizophrenia, schizoaffective disorder, and other nonaffective psychotic disorders as defined by DSM-IV criteria. The marker D1S2836 also had a maximal proportion (0.57, P=0.05) of shared IBD under the broad model. These findings may provide guidance for positional cloning studies on candidate genes in the 1q22–31 and 1q41–44 regions.
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页码:445 / 452
页数:7
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