Pretreatment whole blood Epstein-Barr virus-DNA is a significant prognostic marker in patients with Hodgkin lymphoma

被引:0
作者
Ji Hyun Park
Dok Hyun Yoon
Shin Kim
Jung Sun Park
Chan-sik Park
Heungsup Sung
Sang-Wook Lee
Jooryung Huh
Cheolwon Suh
机构
[1] University of Ulsan,Department of Oncology, Asan Medical Center, College of Medicine
[2] University of Ulsan,Department of Pathology, Asan Medical Center, College of Medicine
[3] University of Ulsan,Department of Laboratory Medicine, Asan Medical Center, College of Medicine
[4] University of Ulsan,Department of Radiation Oncology, Asan Medical Center, College of Medicine
来源
Annals of Hematology | 2016年 / 95卷
关键词
EBV; Hodgkin disease; Whole blood; DNA; Prognosis;
D O I
暂无
中图分类号
学科分类号
摘要
Epstein-Barr virus (EBV) in the peripheral blood has become a significant predictor of clinical outcomes in EBV-associated Hodgkin lymphoma (HL). However, due to its relative rarity, prevalence and prognostic role of circulating EBV-DNA has not been well established in Asian patients. Seventy patients with newly diagnosed HL were prospectively registered between October 2007 and January 2013, and underwent pretreatment whole blood (WB) EBV-DNA quantitation using real-time polymerase chain reaction (RT-PCR). WB EBV-DNA in baseline and serial RT-PCR within 1 year were investigated. Clinicopathologic parameters of the patients according to pretreatment WB EBV-DNA were also explored. Twelve patients (17.1 %) demonstrated WB EBV-DNA(+), which was significantly associated to older age, advanced stages, frequent involvements of extranodal sites, low serum albumin and hemoglobin levels, and high international prognostic scores ≥2. Three-year event-free survival (EFS) and overall survival (OS) were significantly inferior in patients with pretreatment WB EBV-DNA(+) (53.5 vs 67.0 and 65.6 vs 90.2 %) (p < 0.032 and <0.01). Negatively conversed EBV-DNA within 1 year after chemotherapy also significantly affected favorable EFS (p < 0.01). Taken together, pretreatment WB EBV-DNA(+) may be a significant predictor of inferior EFS and OS over EBV-encoded RNA in situ hybridization (EBER-ISH)(+) in Korean patients with HL. Serial EBV-DNA monitoring following chemotherapy also seems helpful to predict survival outcomes.
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页码:801 / 808
页数:7
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