Biomarker Testing to Estimate Under-Reported Heavy Alcohol Consumption by Persons with HIV Initiating ART in Uganda

被引：0

作者：

Judith A. Hahn

Mwebesa B. Bwana

Martin A. Javors

Jeffrey N. Martin

Nneka I. Emenyonu

David R. Bangsberg

机构：

[1] University of California,

[2] Mbarara University of Science and Technology,undefined

[3] University of Texas Health Science Center,undefined

[4] Massachusetts General Hospital,undefined

来源：

AIDS and Behavior | 2010年 / 14卷

关键词：

Carbohydrate-deficient transferrin; Biological markers; Alcohol drinking; HIV; Antiretroviral therapy; Uganda;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Alcohol affects the transmission and treatment of HIV, yet may be under-reported in resource-limited settings. We compared self-reported alcohol consumption with levels of plasma carbohydrate-deficient transferrin (%CDT), a biomarker of heavy alcohol consumption, in persons initiating antiretroviral therapy in Uganda. Almost seven percent (6.7%) of persons reporting abstaining and 10% reporting consuming 1–40 drinks in the prior month tested positive for %CDT, and actual under-report may be higher due to low sensitivity of %CDT. These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical purposes.

引用

页码：1265 / 1268

页数：3

共 33 条

[1]

Fisher JC(2007)The association between HIV infection and alcohol use: a systematic review and meta-analysis of African studies Sex Transm Dis 34 856-863

[2]

Bang H(2009)Alcohol use and antiretroviral adherence: review and meta-analysis J Acquir Immune Defic Syndr 52 180-202

[3]

Kapiga SH(2007)Hepatotoxicity during nevirapine-based fixed-dose combination antiretroviral therapy in kampala, Uganda J Int Assoc Physicians AIDS Care (Chic Ill) 6 83-86

[4]

Hendershot CS(2008)Clinical characteristics of carbohydrate-deficient transferrin (%disialotransferrin) measured by HPLC: sensitivity, specificity, gender effects, and relationship with other alcohol biomarkers Alcohol Alcohol 43 436-441

[5]

Stoner SA(2004)Carbohydrate-deficient transferrin (CDT)–a biomarker for long-term alcohol consumption J Toxicol Environ Health 7 319-337

[6]

Pantalone DW(1996)Carbohydrate-deficient transferrin and gamma-glutamyl transferase levels during disulfiram therapy Alcohol Clin Exp Res 20 1202-1205

[7]

Simoni JM(2003)Improved HPLC method for carbohydrate-deficient transferrin in serum Clin Chem 49 1881-1890

[8]

Hahn JA(2010)Use of carbohydrate-deficient transferrin (CDT) and a combination of GGT and CDT (GGT-CDT) to assess heavy alcohol consumption in traffic medicine Alcohol Alcohol 45 247-251

[9]

Maier M(2007)Biochemical markers of alcoholism Clin Chem Lab Med 45 953-961

[10]

Byakika-Tusiime J(2010)Estimating alcohol content of traditional brew in western Kenya using culturally relevant methods: the case for cost over volume AIDS Behav 14 836-844

← 1 2 3 4 →