Hypophysitis: Evaluation and Management

被引：67
作者：
Faje A. [1 ]
机构：
[1] Massachusetts General Hospital and Harvard Medical School, Neuroendocrine Unit, 55 Fruit Street, Boston, 02114, MA
来源：
Clinical Diabetes and Endocrinology | / 2卷 / 1期
关键词：
Diabetes insipidus; Hypophysitis; Hypopituitarism;
D O I：
10.1186/s40842-016-0034-8
中图分类号：
学科分类号：
摘要：
Hypophysitis is the acute or chronic inflammation of the pituitary gland. The spectrum of hypophysitis has expanded in recent years with the addition of two histologic subtypes and recognition as a complication of treatment with immune checkpoint inhibitors. Despite the increased number of published cases, the pathogenesis of hypophysitis is poorly understood, and treatment strategies are diverse and controversial. The diagnosis of hypophysitis generally requires histopathologic confirmation. The presentation and clinical course of hypophysitis varies. Hypophysitis can resolve spontaneously, relapse may occur, and some cases can be refractory to treatment. © 2016 The Author(s).
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