Effects of dehydroepiandrosterone sulfate on aldosterone levels on exposure to cold

被引:0
作者
T. A. Obut
S. K. Saryg
M. V. Ovsyukova
T. Yu. Dementieva
E. T. Obut
T. A. Erdynieva
机构
[1] Research Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, 630117 Novosibirsk
关键词
Aldosterone; Cold exposure; Dehydroepiandrosterone sulfate; Naltrexone;
D O I
10.1007/s11055-012-9616-9
中图分类号
学科分类号
摘要
Treatment of rats with dehydroepiandrosterone sulfate (DEAS) at doses of 1, 5, and 30 mg/kg were found to block cold-induced increases in blood aldosterone levels, though the effect was not dose-dependent in conditions of repeated cold exposure. This effect of DEAS involved μ opioid receptors. The blocking effect of DEAS (30 mg/kg) was also seen with single episodes of cold exposure, but without the involvement of μ opioid receptors. © 2012 Springer Science+Business Media, Inc.
引用
收藏
页码:651 / 653
页数:2
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