Preparation and characterization of the inclusion complex of hypocrellin A with hydroxypropyl-β-cyclodextrin

被引：0
作者：
Yujie Su
Shengqi Rao
Yujie Cai
Yanjun Yang
机构：
[1] Jiangnan University,State Key Laboratory of Food Science and Technology
[2] Jiangnan University,School of Food Science and Technology
[3] Jiangnan University,School of Biotechnology
来源：
European Food Research and Technology | 2010年 / 231卷
关键词：
Hypocrellin A; Hydroxypropyl-β-cyclodextrin; Inclusion complex; Phase solubility studies; FT-IR spectroscopy; Thermal analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hypocrellin A (HA) is a naturally occurring perylenequinone pigment with bright red colour. The inclusion complex of HA with hydroxypropyl-β-cyclodextrin was prepared successfully by lyophilization method for the first time. Phase solubility studies indicated that the inclusion complex was formed with possible stoichiometry of 1:1. The apparent stability constants and the thermodynamic parameters such as enthalpy change (∆H), entropy change (∆S) and Gibbs free energy (∆G) were calculated in the range of 25–45 °C. The values of apparent stability constants decrease with the increasing of temperature. The thermodynamic results showed that the inclusion process was an exothermic and enthalpy-driven process accompanied with a negative entropic contribution. The formation of inclusion complex was also conformed by Fourier transform infrared spectroscopy, differential scanning calorimetry, thermogravimetry and spectroscopic studies. The inclusion complex showed much better water solubility and dissolution property than the free HA. Therefore, the inclusion complex can be used to expand the application of HA in food, feed and pharmaceutical industries.
引用
收藏
页码：781 / 788
页数：7
相关论文
共 213 条
[1]  
He YY(2000)Synthesis and EPR investigations of new aminated hypcorellin derivatives Free Radical Bio Med 28 1642-1651
[2]  
Jiang LJ(2009)Spectroscopic studies on the interaction of hypocrellin A and hemoglobin Spectrochim Acta Part A 72 151-155
[3]  
Zhou JH(1981)Hypocrellin A–a new drug for photochemotherapy Kexue Tongbao 26 1040-1042
[4]  
Wu XH(2007)Quantum chemical and statistical study of hypocrellin dyes with phototoxicity against tumor cells Dyes Pigments 74 416-423
[5]  
Gu XT(1994)Hypocrellin, from Hypcrella bambusae, is phototoxic to human immunodeficiency virus J Photoch Photobio B 60 253-255
[6]  
Zhou L(2001)Hypericin and hypocrellin induced apoptosis in human mucosal carcinoma cells J Photoch Photobio B 65 59-73
[7]  
Song KX(1999)Synthesis of a new water-soluble phototherapeutic sensitizer from hypocrellin B with enhanced red absorption Dyes Pigments 41 93-100
[8]  
Wei SH(2004)Surface binding and improved photodamage of the lanthanum ion complex of hypocrellin A to calf thymus DNA J Photoch Photobio A 165 143-147
[9]  
Feng YY(1997)Solvent dependence on the intramolecular excited-state proton or hydrogen atom transfer in hypocrellin J Am Chem Soc 119 2763-2764
[10]  
Shen J(2008)Theoretical study of structure, energetic and intramolecular hydrogen transfer of hypocrellin A Chem Phys Lett 466 6-10
12345678910