MET: a promising anticancer therapeutic target

被引:0
作者
Solange Peters
Alex A. Adjei
机构
[1] Centre Pluridisciplinaire d'Oncologie,
[2] Centre Hospitalier Universitaire Vaudois (CHUV),undefined
[3] Roswell Park Cancer Institute,undefined
来源
Nature Reviews Clinical Oncology | 2012年 / 9卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Targeting the MET pathway is an increasingly attractive anticancer strategy. In this Review, this pathway is viewed from the clinical perspective, assessing the available agents in terms of efficacy and toxicity and looking forward to biomarker-driven application in the clinic.
引用
收藏
页码:314 / 326
页数:12
相关论文
共 256 条
[1]  
Birchmeier C(2003)Met, metastasis, motility and more Nat. Rev. Mol. Cell Biol. 4 915-925
[2]  
Birchmeier W(2012)Targeting MET in cancer: rationale and progress Nat. Rev. Cancer 12 89-103
[3]  
Gherardi E(1995)Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer Clin. Cancer Res. 1 147-154
[4]  
Vande Woude GF(2001)Expression of the hepatocyte growth factor/c-Met pathway is increased at the cancer front in breast carcinoma Pathol. Int. 51 172-178
[5]  
Gherardi E(1997)Expression of c-met proto-oncogene in primary colorectal cancer and liver metastases Jpn J. Clin. Oncol. 27 378-383
[6]  
Birchmeier W(1995)Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma Am. J. Pathol. 147 386-396
[7]  
Birchmeier C(2004)Activation of c-Met (hepatocyte growth factor receptor) in human gastric cancer tissue Cancer Sci. 95 803-808
[8]  
Vande Woude G(1997)Expression of scatter factor and cmet receptor in benign and malignant breast tissue Cancer 79 749-760
[9]  
Di Renzo MF(1998)Overexpression of scatter factor and its receptor (c-met) in oral squamous cell carcinoma Laryngoscope 108 1413-1417
[10]  
Edakuni G(2006)Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA665752 Proc. Natl Acad. Sci. USA 103 2316-2321