T-Cell Type Acute Lymphoblastic Leukemia Following Cyclosporin A Therapy for Aplastic Anemia

被引：0
作者：
Yuko Hirose
Yasufumi Masaki
Kazumi Ebata
Jun Okada
Chang gi Kim
Noriyoshi Ogawa
Yuji Wano
Susumu Sugai
机构：
[1] Kanazawa Medical University,Division of Hematology and Immunology, Department of Internal Medicine
[2] Kanazawa Medical University,Division of Hematology and Immunology, Department of Internal Medicine
来源：
International Journal of Hematology | 2001年 / 73卷
关键词：
T-ALL; Cyclosporin A; Aplastic anemia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cyclosporin A (CsA) is used to prevent rejection in transplantation and to treat autoimmune and hematologic diseases such as aplastic anemia. However, the tumor growth-promoting effect of CsA remains controversial. We report the case of a 24-year-old man who developed acute lymphoblastic leukemia of precursor-T-cell origin after 75 months of treatment with CsA for aplastic anemia. The surface antigen phenotype of his leukemic cells was CD2+, CD3+, CD5+, CD7+, CD4−, CD8−, CD10−, CD20−, CD34−, CD41−, and CD56−. Southern blot analysis revealed a monoclonal rearrangement of T-cell receptor—J nongermline fragments inHindIII digestion.
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页码：226 / 229
页数：3
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