Relationship between periodontal destruction and gene mutations in patients with familial Mediterranean fever

被引:0
作者
Ufuk Sezer
Süleyman Ziya Şenyurt
Eda Çetin Özdemir
Orhan Zengin
Kemal Üstün
Kamile Erciyas
Bünyamin Kısacık
Ahmet Mesut Onat
机构
[1] Bezmialem Vakif University,Department of Periodontology
[2] Faculty of Dentistry,Department of Periodontology
[3] Gaziantep University,Department of Rheumatology
[4] Faculty of Dentistry,Department of Periodontology
[5] Ministry of Health,undefined
[6] Center of Oral and Dental Health,undefined
[7] Gaziantep University,undefined
[8] Faculty of Medicine,undefined
[9] Akdeniz University,undefined
[10] Faculty of Dentistry,undefined
来源
Clinical Rheumatology | 2016年 / 35卷
关键词
Familial Mediterranean fever; MEFV mutations; M694V; Periodontitis;
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摘要
Recent studies have shown that genetic factors involved in the host responses might determine the disease severity for both familial Mediterranean fever (FMF) and periodontitis. The present study aimed to investigate the relationship of FMF with periodontitis and to search for the potential association between periodontitis and MEFV gene missense variations in patients with FMF. The study consisted of 97 FMF patients and 34 healthy volunteers. FMF patients were classified according to the kind of MEFV gene mutation: (1) patients with homozygous M694V gene mutation, (2) patients with heterozygous M694V gene mutation, and (3) patients with MEFV gene different mutations. Gingival Index (GI), Plaque Index (PI), probing pocket depth (PD), and clinical attachment level (CAL) were measured in all participants. The results of multivariate logistic regression showed a highly significant association between homozygous M694V gene mutation and periodontitis in FMF patients (p < 0.05). After adjusting for potential confounders (smoking, body weight, age, and gender), FMF patients with homozygous M694V gene mutation were 3.51 (1.08–11.45) times more likely to present periodontitis than the other FMF patients. These results indicate that the presence of homozygous M694V gene mutation seems to increase the risk for periodontitis in FMF patients.
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页码:1841 / 1847
页数:6
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