Self assembly of supramolecular homochiral structures in solutions of chiral biomimetics

The phenomenon of the formation of homochiral sets of supramolecular vortices in xerogels with a low concentration of chiral biomimetics of trifluoroacetylated amino alcohols that are metrically similar to certain macromolecular and macroscopic helical biological structures was discovered and described. Each vortex, with a characteristic scale of ∼ 1 mm, corresponds approximately to the rotational symmetry Sn groups depending on the number of strings that have a common anchorage or are formed from a single nucleation and experience a mutual agreed deviation. It is essential that the direction of deviation is changed to the opposite one with the change of the chirality of the enantiomer and does not depend on the solvent type. Both weakening and strengthening of this trend were observed in the mixtures of various chiral compounds. The result is an important confirmation of the synergetic rule that was proposed by authors. According to this rule, the sign of the chirality of a supramolecular helix is changed to the opposite with a change in the chirality sign of the basic monomers from which it is formed. This regularity has a fundamental character and is executed as a trend in the hierarchies of DNA, protein, and polysaccharide macromolecular structures.