Synthesis and properties of sym-triazine derivatives. 18. Synthesis of N-substituted 2,4-diamino-6-(benzothiazolyl-2-thiomethyl)-sym-triazines

被引：0
作者：
V. I. Kelarev
M. A. Silin
O. A. Borisova
机构：
[1] I. M. Gubkin State Univ. for Oil/Gas
来源：
Chemistry of Heterocyclic Compounds | 2003年 / 39卷 / 5期
关键词：
2,4-diamino-sym-triazines; Benzothiazole; Biguanides; Condensation;
D O I：
10.1023/A:1025102300933
中图分类号：
学科分类号：
摘要：
The condensation of methyl benzothiazolyl-2-thioacetate with N-substituted biguanides in the presence of sodium methylate gave 2-amino-4-(RR′ -amino)-6-(benzothiazolyl-2-thiomethyl)-sym-triazines. In a number of cases the 1,1-disubstituted 5-(benzothiazolyl-2-thioacetyl)biguanides could also be separated and these could be cyclized by refluxing in DMF to the corresponding substituted sym-triazines described. The latter type of compound was also synthesized by treating 2-amino-4-trichloromethyl-6-(benzothiazolyl-2-thiomethyl)-sym-triazine with primary and secondary aliphatic and heterocyclic amines or by the reaction of N-substituted 2,4-diamino-6-chloromethyl-sym-triazines with 2-mercaptobenzothiazole.
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页码：632 / 639
页数：7
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