Adaptogenic effects of chitosan-gold nanocomposites under simulated hypoxic conditions

被引：4
|
作者：
Koryagin A.S. [1 ]
Mochalova A.E. [1 ]
Salomatina E.V. [1 ]
Eshkova O.Yu. [1 ]
Smirnova L.A. [1 ]
机构：
[1] Lobachevsky Nizhni Novgorod State University, Nizhni Novgorod
来源：
Inorganic Materials: Applied Research | 2013年 / 4卷 / 2期
关键词：
blood system; energy metabolism; hypoxia; lactate dehydrogenase; lipid peroxidation; nanostructured system of chitosan-gold; stress;
D O I：
10.1134/S2075113313020081
中图分类号：
学科分类号：
摘要：
Antioxidant and adaptogenic activity of a nanostructured chitosan-gold nanoparticle system was determined on experimental animals under hypoxic conditions. Prophylactic application of the drug leads to a severalfold decrease in the concentration of final products of the lipid peroxidation process, Schiff bases in the blood plasma, and normalization of the activity of one of the key enzymes of energy metabolism, lactate dehydrogenase, after hypoxia. © 2013 Pleiades Publishing, Ltd.
引用
收藏
页码：127 / 130
页数：3
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