Impact of 1α,25-dihydroxyvitamin D3 on biodistribution and pharmacokinetics of L-carnitine and creatinine, organic cation/carnitine transporter 2 and organic cation transporter 2 biomarkers

[1] Agarwal R(2011)Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate Kidney Int 80 1073-1079

[2] Hynson JE(2021)Effects of 1α,25-dihydroxyvitamin D(3) on the pharmacokinetics of procainamide and its metabolite N-acetylprocainamide, organic cation transporter substrates, in rats with PBPK modeling approach Pharmaceutics 13 1133-102

[3] Hecht TJ(1990)Renal function during calcitriol therapy in chronic renal failure Clin Nephrol 33 98-445

[4] Light RP(1975)Turnover of carnitine by rat tissues Biochem J 148 439-19017

[5] Sinha AD(2014)CYP24A1 expression inversely correlates with Melanoma progression: clinic-pathological studies Int J Mol Sci 15 19000-7981

[6] Balla A(2012)A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism Proc Natl Acad Sci USA 109 7974-16

[7] Jeong YS(2020)Therapeutic targets of vitamin D receptor ligands and their pharmacokinetic effects by modulation of transporters and metabolic enzymes J Pharm Invest 50 1-1509

[8] Kim HJ(2016)The complexities of interpreting reversible elevated serum creatinine levels in drug development: does a correlation with inhibition of renal transporters exist? Drug Metab Dispos 44 1498-2367

[9] Lee YJ(2017)Identification of endogenous biomarkers to predict the propensity of drug candidates to cause hepatic or renal transporter-mediated drug-drug interactions J Pharm Sci 106 2357-864

[10] Chung SJ(2018)Clinical probes and endogenous biomarkers as substrates for transporter drug-drug interaction evaluation: perspectives from the international transporter consortium Clin Pharmacol Ther 104 836-99

[1] Agarwal R(2011)Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate Kidney Int 80 1073-1079

[2] Hynson JE(2021)Effects of 1α,25-dihydroxyvitamin D(3) on the pharmacokinetics of procainamide and its metabolite N-acetylprocainamide, organic cation transporter substrates, in rats with PBPK modeling approach Pharmaceutics 13 1133-102

[3] Hecht TJ(1990)Renal function during calcitriol therapy in chronic renal failure Clin Nephrol 33 98-445

[4] Light RP(1975)Turnover of carnitine by rat tissues Biochem J 148 439-19017

[5] Sinha AD(2014)CYP24A1 expression inversely correlates with Melanoma progression: clinic-pathological studies Int J Mol Sci 15 19000-7981

[6] Balla A(2012)A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism Proc Natl Acad Sci USA 109 7974-16

[7] Jeong YS(2020)Therapeutic targets of vitamin D receptor ligands and their pharmacokinetic effects by modulation of transporters and metabolic enzymes J Pharm Invest 50 1-1509

[8] Kim HJ(2016)The complexities of interpreting reversible elevated serum creatinine levels in drug development: does a correlation with inhibition of renal transporters exist? Drug Metab Dispos 44 1498-2367

[9] Lee YJ(2017)Identification of endogenous biomarkers to predict the propensity of drug candidates to cause hepatic or renal transporter-mediated drug-drug interactions J Pharm Sci 106 2357-864

[10] Chung SJ(2018)Clinical probes and endogenous biomarkers as substrates for transporter drug-drug interaction evaluation: perspectives from the international transporter consortium Clin Pharmacol Ther 104 836-99