MRI for assessing and predicting response to neoadjuvant treatment in rectal cancer

被引：0
作者：
Regina G. H. Beets-Tan
Geerard L. Beets
机构：
[1] Maastrict University Medical Centre,Department of Radiology
[2] Maastricht University Medical Center,Department of Surgery
来源：
Nature Reviews Gastroenterology & Hepatology | 2014年 / 11卷
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摘要：
The availability of tools that can accurately measure response is critical for the selection of patients with rectal cancer who can be offered organ-saving treatmentAfter preoperative chemoradiotherapy, endorectal ultrasonography and MRI are limited in the detection of small tumour remnants within the fibrotic tumour bedFunctional MRI combines detailed information on tumour morphology with that on the tumour biological microenvironment and provides comprehensive information on tumour heterogeneityDiffusion-weighted imaging, as a qualitative measure of response is promising for the assessment of clinical complete response, but the evidence so far is mainly from single-centre expert studiesIt is too early to conclude that perfusion magnetic resonance biomarkers could have a role as a measure of response, and many issues need to be resolvedThe future of response evaluation with imaging lies in further exploitation of all information that is within medical images
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页码：480 / 488
页数：8
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共 141 条
[1]  
van de Velde CJ(2014)EURECCA colorectal: multidisciplinary management: European consensus conference colon & rectum Eur. J. Cancer 50 1.e1-1.e34
[2]  
Engelen SM(2013)Modern multidisciplinary treatment of rectal cancer based on staging with magnetic resonance imaging leads to excellent local control, but distant control remains a challenge Eur. J. Cancer 49 2311-2320
[3]  
Maas M(2010)Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data Lancet Oncol. 11 835-844
[4]  
Maas M(2011)Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer J. Clin. Oncol. 29 4633-4640
[5]  
Habr-Gama A(2011)Nonoperative approaches to rectal cancer: a critical evaluation Semin. Radiat. Oncol. 21 234-239
[6]  
Perez RO(2010)Complete clinical response after neoadjuvant chemoradiation therapy for distal rectal cancer: characterization of clinical and endoscopic findings for standardization Dis. Colon Rectum 53 1692-1698
[7]  
Sao Juliao GP(2012)Role of biopsies in patients with residual rectal cancer following neoadjuvant chemoradiation after downsizing: can they rule out persisting cancer? Colorectal Dis. 14 714-720
[8]  
Proscurshim I(2013)Predicting outcomes in radiation oncology—multifactorial decision support systems Nat. Rev. Clin. Oncol. 10 27-40
[9]  
Gama-Rodrigues J(2011)Development and external validation of a predictive model for pathological complete response of rectal cancer patients including sequential PET-CT imaging Radiother. Oncol. 98 126-133
[10]  
Habr-Gama A(2012)Pathological grading of regression following neoadjuvant chemoradiation therapy: the clinical need is now J. Clin. Pathol. 65 867-871
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