Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B12 in the acute phase of atherothrombotic stroke

被引：0

作者：

Giuseppe Salemi

M. C. Gueli

M. D’Amelio

V. Saia

P. Mangiapane

P. Aridon

P. Ragonese

I. Lupo

机构：

[1] University of Palermo,Section of Neurology, Department of Clinical Neuroscience

[2] University of Palermo,Department of Biochemical Sciences

来源：

Neurological Sciences | 2009年 / 30卷

关键词：

Large artery atherothrombotic stroke; Homocysteine; Cysteine; Folic acid; Vitamin B; Reduced glutathione;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Blood levels of total homocysteine (tHcy), cysteine (Cys), total and reduced glutathione (tGSH and rGSH), folic acid (FA), and vitamin B12 (B12) change during ischemic stroke as accompaniment of the tissue damage. The relationship between these changes remains scantly investigated. We evaluated the variation of these molecules in the 48 h after acute large artery atherothrombotic stroke (LAAS) and searched for the presence of matched variation of them. The study involved 50 subjects affected by acute LAAS and 49 healthy controls. Plasma levels of tHcy and Cys were significantly higher and serum levels of FA and B12 and plasma levels of rGSH were significantly lower in the patients than in the control group. Acute LAAS was associated with increased Hcy—decreased tGSH and decreased FA/tGSH. Pathways involved in cellular stress and in tissue repair are activated during acute LAAS.

引用

页码：361 / 364

页数：3

共 61 条

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