Anticancer activities of some arylcarbamoylalkyltriphenylphosphonium chlorides

被引：0
作者：
Lou Zhaowen
Zhou Li
Xiao Chunfen
Ye Yong
Zeng Fanbo
Huang Kaixun
机构：
[1] Hua Zhong University of Science and Technology,Department of chemistry
[2] Hubei University,Key Laboratory of Synthesis and Application of Organic Functional Molecules of the Education Ministry
来源：
Medicinal Chemistry Research | 2007年 / 16卷
关键词：
Phosphonium; Synthesis; Characterization; Anticancer activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel arylcarbamoylalkyltriphenylphosphonium chlorides were synthesized. The newly synthesized compounds, [R-(p-C6H4)-NH-CO-R1P⊕(C6H4)3]Clθ, R = H (2), CH3 (4), NO2 (6), R1 = –CH2− (b), CH3CH< (a), –CH2CH2− (c), –CH2CH2CH2 (d), the analogs of an anticancer drug, were characterized by infrared (IR), 1H nuclear magnetic resonance (NMR), 13C-NMR, 31P-NMR, mass spectrometry (MS), thermogravimetry (TG), and conductivity measurements. The anticancer activities of the obtained compounds were measured by MTT. The preliminary results indicated that some compounds showed potent anticancer activities against HCT-8, Bel-7402, A549, and S180.
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页码：380 / 391
页数：11
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