WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma

被引：0
作者：
Daniela Maria Rasà
Agata Grazia D’Amico
Grazia Maugeri
Sebastiano Cavallaro
Velia D’Agata
机构：
[1] University of Catania,Sections of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences
[2] San Raffaele Open University of Rome,Department of Human Science and Promotion of Quality of Life
[3] Italian National Research Council Catania,Institute of Neurological Sciences
来源：
Journal of Molecular Neuroscience | 2017年 / 62卷
关键词：
WT1; Alternative splicing; Isoforms; Neuroblastoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Wilms tumor 1 (WT1), a tumor suppressor gene, was originally identified in the homonymous renal neoplasm but is also involved in other cancers. Its function is still unclear, since it acts both as a pro- and an anti-oncogene. At least 14 WT1 transcriptional variants have been described; yet most investigations have focused on a small number of isoforms. We describe their structural features and review the evidence of their involvement in cancer with emphasis on neuroblastoma. In future, full characterization of all WT1 isoforms is expected to identify new molecular tumor markers and/or therapeutic targets.
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页码：131 / 141
页数：10
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