Single-particle virology

被引：9
作者：
Kiss B. [1 ]
Mudra D. [1 ]
Török G. [1 ]
Mártonfalvi Z. [1 ]
Csík G. [1 ]
Herényi L. [1 ]
Kellermayer M. [1 ]
机构：
[1] Department of Biophysics and Radiation Biology, Semmelweis University, Budapest
来源：
Biophysical Reviews | 2020年 / 12卷 / 5期
关键词：
Atomic force microscopy; Optical tweezers; Single-molecule mechanics; Super-resolution microscopy; Viral genome packaging; Viral genome release;
D O I：
10.1007/s12551-020-00747-9
中图分类号：
学科分类号：
摘要：
The development of advanced experimental methodologies, such as optical tweezers, scanning-probe and super-resolved optical microscopies, has led to the evolution of single-molecule biophysics, a field of science that allows direct access to the mechanistic detail of biomolecular structure and function. The extension of single-molecule methods to the investigation of particles such as viruses permits unprecedented insights into the behavior of supramolecular assemblies. Here we address the scope of viral exploration at the level of individual particles. In an era of increased awareness towards virology, single-particle approaches are expected to facilitate the in-depth understanding, and hence combating, of viral diseases. © 2020, The Author(s).
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页码：1141 / 1154
页数：13
相关论文
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