Effect of NO Synthase Blockade on NO Production in Rat Heart under Conditions of Hypokinesia

被引：0
作者：
R. I. Zaripova
Kh. L. Gainutdinov
T. L. Zefirov
机构：
[1] Kazan (Volga Region) Federal University,Department of Anatomy Physiology, and Human Health Protection
[2] Russian Academy of Sciences,Kazan E. K. Zavoisky Physical
来源：
Bulletin of Experimental Biology and Medicine | 2014年 / 157卷
关键词：
NO; heart; rat; hypokinesia; electron paramagnetic resonance;
D O I：
暂无
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学科分类号：
摘要：
Electron paramagnetic (EPR) spectroscopy study showed that 90-day hypokinesia in rats is accompanied by an increase in NO production in the heart. A nonselective NO synthase inhibitor L-NAME decreased the content of NO in the heart atria and ventricles of hypokinetic rats by 67-70%. A selective inhibitor of inducible NO synthase, aminoguanidine, also decreased the level of NO in the heart atria and ventricles of hypokinetic rats by 60-65%. Our results indicate that the increase in NO production during hypokinesia is associated with activation of NO synthases.
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页码：545 / 547
页数：2
相关论文
共 36 条
  • [1] Gainutdinov KL(2013)undefined Biofizika 58 276-280
  • [2] Andrianov VV(2013)undefined Bull. Exp. Biol. Med. 155 708-710
  • [3] Iyudin VS(2001)undefined Bull. Exp. Biol. Med. 132 943-945
  • [4] Zefirov TL(2011)undefined Dokl. Akad. Nauk 441 406-409
  • [5] Ziyatdinova NI(2007)undefined Uspekhi Biol. Khim. 47 259-292
  • [6] Zefirov AL(2007)undefined Uspekhi Fiziol. Nauk 38 39-58
  • [7] Kamskova YG(2001)undefined Biochem. J. 357 593-615
  • [8] Kuropteva ZV(2009)undefined Antioxid. Redox Signal. 11 2717-2739
  • [9] Reutov VP(2010)undefined Nitric Oxide 23 1-11
  • [10] Baider LM(2006)undefined Diabetes 55 496-505
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