Botulinum toxin in children with cerebral palsy

被引：14
作者：
Singhi P. [1 ,2 ]
Ray M. [1 ]
机构：
[1] Advanced Pediatric Centre, Postgrad. Inst. of Medical Sciences, Chandigarh
[2] Chf. Pediat. Neurol. and Neurodevmt., Advanced Pediatrics Centre, Postgrad. Inst. of Medical Sciences
来源：
The Indian Journal of Pediatrics | 2004年 / 71卷 / 12期
关键词：
Botulinum toxin; Cerebral palsy; Spasticity;
D O I：
10.1007/BF02829820
中图分类号：
学科分类号：
摘要：
Botulinum toxin is a neurotoxin that blocks the synaptic release of acetylcholine from cholinergic nerve terminals mainly at the neuromuscular junction, resulting in irreversible loss of motor end plates. It is being widely tried as a targeted antispasticity treatment in children with cerebral palsy. A number of studies have shown that it reduces spasticity and increases the range of motion and is particularly useful in cases with dynamic contractures. However improvement in function has not been convincingly demonstrated. It is an expensive mode of therapy and the injections need to be repeated after 3-6 months. Whereas Botulinum toxin can be a valuable adjunct in select cases, it should not be projected as a panacea for children with spastic cerebral palsy.
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收藏
页码：1087 / 1091
页数：4
相关论文
共 61 条
[1]  
Davies L.E., Botulinum toxin: From poison to medicine, Western J Med, 158, pp. 25-29, (1993)
[2]  
Burgen A.S.V., Dickens F., Zatinam L.J., The action of botulinum toxin on the neuromuscular junction, J Physiol, 109, pp. 10-24, (1949)
[3]  
De Paiva A., Meunier F.A., Molgo J., Aoki K.R., Dolly J.O., Functional repair of motor endplates after botulinum neurotoxin type A poisoning: Biphasic switch of synaptic activity between nerve sprouts and their parent terminals, Proc Natl Acad Sci USA, 96, pp. 3200-3205, (1999)
[4]  
Van Ermengen E., Uber einen neuen anaeroben bacillus and seine Beziehungen zum botulismus, Z Hyg Infektionskrank, 26, pp. 1-56, (1897)
[5]  
Scott A.B., Rosenbaum A., Collins C.C., Pharmacological weakening of extraocular muscles, Invest Opthalmol Vis Sci, 12, pp. 924-927, (1973)
[6]  
Scott A.B., Botulinum toxin injection of eye muscles to correct strabismus, Trans Am Ophthalmol Soc, 79, pp. 734-770, (1981)
[7]  
Jankovic J., Brin M.F., Botulinum toxin: Historical perspective and potential new indications, Muscle Nerve, SUPPL. 6, (1997)
[8]  
Brin M.F., Botulinum toxin: New and expanded indications, Eur J Neurol, 4, (1997)
[9]  
Verheyden J., Blitzer A., Other noncosmetic uses of BOTOX, Dis Mon, 48, pp. 357-366, (2002)
[10]  
Middlebrook J.L., Cell surface receptors for protein toxins, Botulinum Neurotoxin and Tetanus Toxin, pp. 95-119, (1989)
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