A phase I, placebo-controlled, randomized, double-blind, single ascending dose-ranging study to evaluate the safety and tolerability of a novel biophysical bronchodilator (S-1226) administered by nebulization in healthy volunteers

被引:0
作者
Francis H. Y. Green
Richard Leigh
Morenike Fadayomi
Gurkeet Lalli
Andrea Chiu
Grishma Shrestha
Sharif G. ElShahat
David Evan Nelson
Tamer Y. El Mays
Cora A. Pieron
John H. Dennis
机构
[1] University of Calgary,Department of Pathology & Laboratory Medicine
[2] University of Calgary,Department of Medicine
[3] SolAeroMed Inc.,undefined
来源
Trials | / 17卷
关键词
Asthma; CO; Perflubron; Phase I; Safety; S-1226; Biophysical drug;
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[1]  
Ismaila AS(2013)Clinical, economic, and humanistic burden of asthma in Canada: a systematic review BMC Pulm Med 13 70-41
[2]  
Sayani AP(2011)Management of severe acute asthma in the emergency department Curr Opin Crit Care 17 335-35
[3]  
Marin M(2013)Severe refractory asthma: an update Eur Respir Rev 22 227-8
[4]  
Su Z(2010)Increased myoepithelial cells of bronchial submucosal glands in fatal asthma Thorax 65 32-9
[5]  
Rowe BH(2009)Intubation and mechanical ventilation of the asthmatic patient in respiratory failure Proc Am Thor Soc 6 371-49
[6]  
Sevcik W(1987)The “sick” building syndrome in the office environment: the Danish town hall study Environ Int 13 339-61
[7]  
Villa-Roel C(2015)Neural control of breathing and CO Neuron 87 946-70
[8]  
Wener RR(1976) homeostasis Am Rev Respir Dis 114 861-12
[9]  
Bel EH(1965)Site of action of inhaled 6 per cent carbon dioxide in the lungs of asthmatic subjects before and after exercise N Engl J Med 272 6-51
[10]  
Green FH(1947)Carbon dioxide titration curve of normal man: effects of increasing degrees of acute hypercapnia on acid-base equilibrium Am J Physiol 149 43-23