Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir

[1] Richman DD(2009)The challenge of finding a cure for HIV infection Science (80- ). 323 1304-1307

[2] Margolis DM(2009)HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation Nat Med 15 893-900

[3] Delaney M(2007)HIV-1 proviral DNA excision using an evolved recombinase Science (80- ) 316 1912-1915

[4] Greene WC(2013)Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells Nucleic Acids Res 41 7771-7782

[5] Hazuda D(2013)Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus Sci Rep 3 2510-11466

[6] Pomerantz RJ(2014)RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection Proc Natl Acad Sci U S A 111 11461-489

[7] Chomont N(2015)The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA Retrovirology 12 22-98

[8] El-Far M(2016)CRISPR/Cas9-derived mutations both inhibit HIV-1 replication and accelerate viral escape Cell Rep 15 481-2826

[9] Ancuta P(2016)Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy Antivir Res 126 90-E4996

[10] Trautmann L(2016)A combinatorial CRISPR-Cas9 attack on HIV-1 DNA extinguishes all infectious provirus in infected T cell cultures Cell Rep ElsevierCompany 17 2819-13480

[1] Richman DD(2009)The challenge of finding a cure for HIV infection Science (80- ). 323 1304-1307

[2] Margolis DM(2009)HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation Nat Med 15 893-900

[3] Delaney M(2007)HIV-1 proviral DNA excision using an evolved recombinase Science (80- ) 316 1912-1915

[4] Greene WC(2013)Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells Nucleic Acids Res 41 7771-7782

[5] Hazuda D(2013)Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus Sci Rep 3 2510-11466

[6] Pomerantz RJ(2014)RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection Proc Natl Acad Sci U S A 111 11461-489

[7] Chomont N(2015)The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA Retrovirology 12 22-98

[8] El-Far M(2016)CRISPR/Cas9-derived mutations both inhibit HIV-1 replication and accelerate viral escape Cell Rep 15 481-2826

[9] Ancuta P(2016)Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy Antivir Res 126 90-E4996

[10] Trautmann L(2016)A combinatorial CRISPR-Cas9 attack on HIV-1 DNA extinguishes all infectious provirus in infected T cell cultures Cell Rep ElsevierCompany 17 2819-13480