A yeast artificial chromosome contig spanning the mouse immunoglobulin kappa light chain locus

被引：0
|
作者：
Ingo W. Schupp
Thomas Schlake
Thomas Kirschbaum
Hans G. Zachau
T. Boehm
机构：
[1] Deutsches Krebsforschungszentrum,
[2] Im Neuenheimer Feld 280,undefined
[3] D-69120 Heidelberg,undefined
[4] Germany,undefined
[5] Adolf-Butenandt-Institut für Physiologische Chemie der Universität München,undefined
[6] Schillerstraße 44,undefined
[7] D-80366 München,undefined
[8] Germany,undefined
来源：
Immunogenetics | 1997年 / 45卷
关键词：
Gene Family; Gene Cluster; Bacterial Artificial Chromosome; Mouse Genome; Bacterial Artificial Chromosome Clone;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
 A single contig spanning the entire mouse immunoglobulin kappa light chain (Igk) locus on chromosome 6 has been established using yeast and bacterial artificial chromosome clones. Detailed mapping of the Igk locus indicates that a member of the Igk-V2 gene family, located about 3.5 megabases upstream of the Igk-J-C complex, is the most distal functional Igk-V gene. Sequence analyses of Igk-V genes and anonymous DNA segments provide indications for internal duplications at the 5′ end of the Igk-V locus and identify the likely origin of Igk-V orphon gene clusters located elsewhere in the mouse genome.
引用
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页码：180 / 187
页数：7
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