Geometry reconstruction method for patient-specific finite element models for the assessment of tibia fracture risk in osteogenesis imperfecta

被引：0
作者：
Christiane Caouette
Nicole Ikin
Isabelle Villemure
Pierre-Jean Arnoux
Frank Rauch
Carl-Éric Aubin
机构：
[1] Polytechnique Montréal,Canada Research Chair in Orthopedic Engineering, Department of Mechanical Engineering
[2] Sainte-Justine University Hospital Center,IFSTTAR
[3] Aix-Marseille University,Canada Research Chair in Mechanobiology of the Pediatric Musculoskeletal System, Department of Mechanical Engineering
[4] Shriners Hospital for Children,undefined
[5] McGill University,undefined
[6] iLab-Spine (International Laboratory - Spine Imaging and Biomechanics),undefined
[7] iLab-Spine (International Laboratory - Spine Imaging and Biomechanics),undefined
[8] Polytechnique Montréal,undefined
来源：
Medical & Biological Engineering & Computing | 2017年 / 55卷
关键词：
Osteogenesis imperfecta; Finite element modeling; Patient-specific geometry; Tibia bowing;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Lower limb deformation in children with osteogenesis imperfecta (OI) impairs ambulation and may lead to fracture. Corrective surgery is based on empirical assessment criteria. The objective was to develop a reconstruction method of the tibia for OI patients that could be used as input of a comprehensive finite element model to assess fracture risks. Data were obtained from three children with OI and tibia deformities. Four pQCT scans were registered to biplanar radiographs, and a template mesh was deformed to fit the bone outline. Cortical bone thickness was computed. Sensitivity of the model to missing slices of pQCT was assessed by calculating maximal von Mises stress for a vertical hopping load case. Sensitivity of the model to ±5 % of cortical thickness measurements was assessed by calculating loads at fracture. Difference between the mesh contour and bone outline on the radiographs was below 1 mm. Removal of one pQCT slice increased maximal von Mises stress by up to 10 %. Simulated ±5 % variation of cortical bone thickness leads to variations of up to 4.1 % on predicted fracture loads. Using clinically available tibia imaging from children with OI, the developed reconstruction method allowed the building of patient-specific finite element models.
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页码：549 / 560
页数：11
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