Ultrasound-promoted synthesis of novel 2-chloroquinolin-4-pyrimidine carboxylate derivatives as potential antibacterial agents

被引：0

作者：

G. L. Balaji

K. Rajesh

Shabana Kouser Ali

V. Vijayakumar

机构：

[1] VIT University,Synthetic Organic Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences

[2] VIT University,School of Biosciences and Technology

来源：

Research on Chemical Intermediates | 2013年 / 39卷

关键词：

2,4-Dichloroquinolines; Pyrimidone; Sonication; Antibacterial activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Ultrasound-promoted reaction of substituted 2,4-dichloroquinolines (1) with ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (2) in the presence of K2CO3 as mild base at moderate temperatures leads to 2-chloroquinolin-4-pyrimidine carboxylate derivatives (3) with high regioselectivity. All the compounds synthesized were characterized by use of spectral data and screened for their antibacterial activity against two Gram-positive (Staphylococcus aureus, Bacillus cereus) and two Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. Activity was moderate.

引用

页码：1807 / 1815

页数：8

共 50 条

[41] Novel amide derivatives containing an imidazo[1,2-a]pyridine moiety: Design, synthesis as potential nematicidal and antibacterial agents [J].

Wei, Chengqian ;

Huang, Junjie ;

Luo, Yuqin ;

Wang, Shaobo ;

Wu, Sikai ;

Xing, Zhifu ;

Chen, Jixiang .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2021, 175

[42] Synthesis and Antimicrobial Evaluation of Aminoguanidine and 3-amino-1,2,4-triazole Derivatives as Potential Antibacterial Agents [J].

Zhang, Tian-Yi ;

Li, Chao ;

Li, Ya-Ru ;

Li, Xiao-Zhen ;

Sun, Liang-Peng ;

Zheng, Chang-Ji ;

Piao, Hu-Ri .

LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 13 (10) :1063-1075

[43] Synthesis of New Thiazole and Pyrazole Clubbed 1,2,3-Triazol Derivatives as Potential Antimycobacterial and Antibacterial Agents [J].

Jagadale, Shivaji M. ;

Abhale, Yogita K. ;

Pawar, Hari R. ;

Shinde, Abhijit ;

Bobade, Vivek D. ;

Chavan, Abhijit P. ;

Sarkar, Dhiman ;

Mhaske, Pravin C. .

POLYCYCLIC AROMATIC COMPOUNDS, 2022, 42 (06) :3216-3237

[44] Ultrasound-assisted efficient synthesis of polyfunctional 1,2,4-triazoles as novel antibacterial and antioxidant agents [J].

Dastmard, Sahar ;

Mamaghani, Manouchehr ;

Rassa, Mehdi .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2020, 67 (08) :1437-1445

[45] Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents [J].

Gavade, Sandip N. ;

Markad, Vijay L. ;

Kodam, Kisan M. ;

Shingare, Murlidhar S. ;

Mane, Dhananjay V. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (15) :5075-5077

[46] Design, Synthesis and Biological Evaluation of 3-(4-Halophenyl)-3-oxopropanal and Their Derivatives as Novel Antibacterial Agents [J].

Liu, Jinbing ;

Yi, Wei ;

Hu, Jianming ;

Wu, Fengyan ;

Zhao, Liangzhong ;

Song, Huacan ;

Wang, Zhihou .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, 58 (09) :1127-1131

[47] Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents [J].

Xue, Tao ;

Ding, Shi ;

Guo, Bin ;

Chu, Wenjing ;

Wang, Hui ;

Yang, Yushe .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (10) :2203-2210

[48] Some New 1,2,4-triazole Derivatives Bearing the Pyrimidine Moiety as Potential Antimycobacterial Agents: Synthesis and Docking Analysis [J].

Reddy, Ganji Sreekanth ;

Rao, Anna Venkateswara ;

Prasad, Mukkanti Siva Naga Anjaneya ;

Viswanath, Ivaturi Venkata Kasi ;

Laxminarayana, Eppakayala .

LETTERS IN DRUG DESIGN & DISCOVERY, 2023, 20 (10) :1664-1674

[49] Synthesis and QSAR studies of 4-oxo-thiazolidines and 2-oxo-azetidines as potential antibacterial agents [J].

Desai, N. C. ;

Shah, M. D. ;

Bhavsar, A. M. ;

Saxena, A. K. .

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2008, 47 (07) :1135-1144

[50] Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents [J].

Song, Zhong-Cheng ;

Ma, Gao-Yuan ;

Lv, Peng-Cheng ;

Li, Huan-Qiu ;

Xiao, Zhu-Ping ;

Zhu, Hai-Liang .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) :3903-3908

← 1 2 3 4 5 →