Ultrasound-promoted synthesis of novel 2-chloroquinolin-4-pyrimidine carboxylate derivatives as potential antibacterial agents

被引：0

作者：

G. L. Balaji

K. Rajesh

Shabana Kouser Ali

V. Vijayakumar

机构：

[1] VIT University,Synthetic Organic Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences

[2] VIT University,School of Biosciences and Technology

来源：

Research on Chemical Intermediates | 2013年 / 39卷

关键词：

2,4-Dichloroquinolines; Pyrimidone; Sonication; Antibacterial activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Ultrasound-promoted reaction of substituted 2,4-dichloroquinolines (1) with ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (2) in the presence of K2CO3 as mild base at moderate temperatures leads to 2-chloroquinolin-4-pyrimidine carboxylate derivatives (3) with high regioselectivity. All the compounds synthesized were characterized by use of spectral data and screened for their antibacterial activity against two Gram-positive (Staphylococcus aureus, Bacillus cereus) and two Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. Activity was moderate.

引用

页码：1807 / 1815

页数：8

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