Nanoparticles: Oral Delivery for Protein and Peptide Drugs

被引：0
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作者：
Shu-jun Cao
Shuo Xu
Hui-ming Wang
Yong Ling
Jiahua Dong
Rui-dong Xia
Xiang-hong Sun
机构：
[1] Pharmacy College of Qingdao University,
[2] Stomatology College of Qingdao University,undefined
[3] Affiliated Hospital of Qingdao University,undefined
来源：
AAPS PharmSciTech | / 20卷
关键词：
protein and peptide drugs; nanoparticles; oral delivery; bioavailability;
D O I：
暂无
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学科分类号：
摘要：
Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems. The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic.
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