Blood Pressure in Relation to Coffee and Caffeine Consumption

被引：0

作者：

Idris Guessous

Chin B. Eap

Murielle Bochud

机构：

[1] University Hospital of Geneva,Unit of Population Epidemiology, Department of Community Medicine and Primary Care and Emergency Medicine

[2] Lausanne University Hospital,Institute of Social and Preventive Medicine (IUMSP)

[3] Centre Hospitalier Universitaire Vaudois,Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, Department of Psychiatry

[4] University of Lausanne,undefined

[5] Hospital of Cery,undefined

[6] School of Pharmaceutical Sciences,undefined

[7] University of Geneva,undefined

[8] University of Lausanne,undefined

来源：

Current Hypertension Reports | 2014年 / 16卷

关键词：

Blood pressure; Hypertension; Coffee; Caffeine; CYP1A2; Genetics; Enzyme; Smoking; Adenosine; Renal sodium reabsorption;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The relationship between blood pressure (BP) and coffee is of major interest given its widespread consumption and the public health burden of high BP. Yet, there is no specific recommendation regarding coffee intake in existing hypertension guidelines. The lack of a definitive understanding of the BP-coffee relationship is partially attributable to issues that we discuss in this review, issues such as acute vs. chronic effects, genetic and smoking effect modifications, and coffee vs. caffeine effects. We also present evidence from meta-analyses of studies on the association of BP with coffee intake. The scope of this review is limited to the latest advances published with a specific focus on caffeine, acknowledging that caffeine is only one among numerous components in coffee that may influence BP. Finally, considering the state of the research, we propose a mechanism by which the CYP1A2 gene and enzyme influence BP via inhibition of the adenosine receptor differentially in smokers and non-smokers.

引用

共 174 条

[21]

Welch WJ(2012)Influence of cytochrome P450 oxidoreductase genetic polymorphisms on CYP1A2 activity and inducibility by smoking Pharmacogenet Genomics 22 143-51

[22]

Schreiner GF(2013)Pharmacogenetics of CYP1A2 activity and inducibility in smokers and exsmokers Pharmacogenet Genomics 23 286-92

[23]

Belardinelli L(2008)Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms Pharmacogenomics 9 625-37

[24]

Djordjevic N(1999)Functional significance of a C– > A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine Br J Clin Pharmacol 47 445-9

[25]

Ghotbi R(2011)Impact of smoking, smoking cessation, and genetic polymorphisms on CYP1A2 activity and inducibility Clin Pharmacol Ther 90 117-25

[26]

Bertilsson L(2008)On the use of Mendelian randomization to infer causality in observational epidemiology Eur Heart J 29 2456-7

[27]

Jankovic S(2008)A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology Int J Epidemiol 37 414-6

[28]

Aklillu E(2009)Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2 AAPS J 11 481-94

[29]

Svilaas A(2013)Comparison of nine common coffee extraction methods: instrumental and sensory analysis Eur Food Res Technol 236 607-27

[30]

Sakhi AK(2006)Caffeine content of decaffeinated coffee J Anal Toxicol 30 611-3

← 1 2 3 4 5 6 7 8 9 10 →