Enzyme dynamics and catalysis in the mechanism of DNA polymerase

被引：0
|
作者：
Adrian J. Mulholland
Adrian E. Roitberg
Iñaki Tuñón
机构：
[1] University of Bristol,Centre for Computational Chemistry, School of Chemistry
[2] University of Florida,Department of Chemistry and Quantum Theory Project
[3] Universidad de Valencia,Departamento de Química Física
来源：
Theoretical Chemistry Accounts | 2012年 / 131卷
关键词：
Enzyme dynamics; Enzymatic catalysis; Dynamical effects; DNA polymerase;
D O I：
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中图分类号：
学科分类号：
摘要：
This contribution contains the commentaries of the three authors about two papers in this issue of TCA that present alternative views of the role of conformational changes in the specificity of enzyme DNA polymerase β. Concepts such as dynamical effects, the induced fit model or the importance of sampling in modeling of enzymatic reactions are briefly revised within the context of the debate established in the two previous papers.
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