Novel Strategies for Allergy Immunotherapy

被引：0
作者：
Reisacher W.R. [1 ]
Wang A. [1 ]
机构：
[1] Presbyterian Hospital/Weill Cornell Medical College, 1305 York Avenue, 5th Floor, New York, 10021, NY
来源：
Current Otorhinolaryngology Reports | 2013年 / 1卷 / 2期
关键词：
Allergy; Antigen-presenting cells; Antigens; Asthma; Delivery; Epitopes; Immunotherapy; Oral mucosa; Peptide; Recombinant; Rhinoconjunctivitis; Subcutaneous; Sublingual;
D O I：
10.1007/s40136-013-0009-6
中图分类号：
学科分类号：
摘要：
This article reviews the literature on allergen modifications and novel routes of delivery for antigen-specific immunotherapy for allergic disease. Allergen modifications include the use of recombinant proteins, combining antigens with infectious carrier proteins, peptide immunotherapy, and genetic vaccines containing the code for allergenic proteins. Novel routes of delivery include oral immunotherapy, intralymphatic immunotherapy, epicutaneous immunotherapy, and oral mucosal immunotherapy. Allergen depot preparations, such as biodegradable, injectable microspheres and sublingual tablets, have also been developed. Current research in immunotherapy for allergic disease has focused on improving efficacy and patient adherence to therapy, while minimizing the risks of serious adverse events. © 2013, Springer Science+Business Media New York.
引用
收藏
页码：119 / 126
页数：7
相关论文
共 89 条
[1]  
Prevalence of Selected Chronic Conditions, (1994)
[2]  
Canonnica G.W., Bousquet J., Casale T., Et al., Sub-lingual immunotherapy: world allergy organization position paper 2009, Allergy., 64, pp. 1-59, (2009)
[3]  
Maggi E., T cell responses induced by allergen-specific immunotherapy, Clin Exp Immunol., 161, 1, pp. 10-18, (2010)
[4]  
Scadding G., Durham S., Mechanisms of sublingual immunotherapy, J Asthma., 46, pp. 322-334, (2009)
[5]  
Durham S.R., Walker S.M., Varga E.M., Et al., Long-term clinical efficacy of grass-pollen immunotherapy, N Engl J Med., 341, pp. 468-475, (1999)
[6]  
Silvestri M., Rossi G.A., Cozzani S., Et al., Age-dependent tendency to become sensitized to other classes of aeroallergens in atopic asthmatic children, Ann Allergy Asthma Immunol., 83, pp. 335-340, (1999)
[7]  
Jacobsen L., Niggemann B., Dreborg S., Et al., Specific immunotherapy has long-term preventative effect of seasonal and perennial asthma: 10-year follow-up on the PAT study, Allergy., 62, pp. 943-948, (2007)
[8]  
Noon L., Prophylactic inoculation against hay fever, Lancet., 1, pp. 1572-1573, (1911)
[9]  
Seiberling K., Hiebert J., Nyirady J., Et al., Cost of allergy immunotherapy: sublingual vs subcutaneous administration, Int Forum Allergy Rhinol., pp. 1-5, (2012)
[10]  
Bousquet J., Lockey R., Malling H.J., Et al., Allergen immunotherapy: therapeutic vaccines for allergic disease. world health organization. American academy of allergy, asthma and immunology, Ann Allergy Asthma Immunol., 81, pp. 401-405, (1998)
123456789