Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report

被引：0
作者：
M Mohty
C Faucher
B Gaugler
N Vey
D Sainty
C Arnoulet
MJ Mozziconacci
D Isnardon
JA Gastaut
D Maraninchi
D Olive
D Blaise
机构：
[1] Laboratoire d'Immunologie des Tumeurs,Département d'Hématologie
[2] Institut Paoli-Calmettes,undefined
[3] Université de la Méditerranée,undefined
[4] Unité de Transplantation et de Thérapie Cellulaire (UTTC),undefined
[5] Institut Paoli-Calmettes,undefined
[6] INSERM U119,undefined
[7] Institut Paoli-Calmettes,undefined
[8] Université de la Méditerranée,undefined
来源：
Bone Marrow Transplantation | 2001年 / 28卷
关键词：
LGL; anti-tumor activity; allo-BMT; non-myeloablative; GVT;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.
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页码：1157 / 1160
页数：3
相关论文
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